Adipose Derived Tissue Engineered Heart Valve
نویسندگان
چکیده
منابع مشابه
Tissue engineered aortic valve
Several prostheses are available to replace degenerative diseased aortic valves with unique advantages and disadvantages. Bioprotheses show excellent hemodynamic behavior and low risk of thromboembolic complications, but are limited by tissue deterioration. Mechanical heart valves have extended durability, but permanent anticoagulation is mandatory. Tissue engineering created a new generation h...
متن کاملDynamic Flexure Independently Stimulates Engineered Heart Valve Tissue Development
The independent effect of dynamic flexure on the development of tissue engineered heart valves (TEHV) was investigated. Engineered heart valve tissues were constructed by seeding ovine smooth muscle cells onto rectangular scaffold strips and incubating the resultant constructs in a dynamic flexure bioreactor or under static conditions for three weeks. Tests indicated a trend of higher effective...
متن کاملExtracellular matrix production by adipose-derived stem cells: implications for heart valve tissue engineering.
A key challenge in tissue engineering a heart valve is to reproduce the major tissue structures responsible for native valve function. Here we evaluated human adipose-derived stem cells (ADSCs) as a source of cells for heart valve tissue engineering investigating their ability to synthesize and process collagen and elastin. ADSCs were compared with human bone marrow mesenchymal stem cells (BmMS...
متن کاملDecellularized tissue-engineered heart valve leaflets with recellularization potential.
Tissue-engineered heart valves (TEHV) have been proposed as a promising solution for the clinical needs of pediatric patients. In vivo studies have shown TEHV leaflet contraction and regurgitation after several months of implantation. This has been attributed to contractile cells utilized to produce the extracellular matrix (ECM) during TEHV culture. Here, we utilized such cells to develop a ma...
متن کاملBiomechanical properties of native and tissue engineered heart valve constructs.
Due to the increasing number of heart valve diseases, there is an urgent clinical need for off-the-shelf tissue engineered heart valves. While significant progress has been made toward improving the design and performance of both mechanical and tissue engineered heart valves (TEHVs), a human implantable, functional, and viable TEHV has remained elusive. In animal studies so far, the implanted T...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Tissue Science & Engineering
سال: 2015
ISSN: 2157-7552
DOI: 10.4172/2157-7552.1000156